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Article

Luteolin reduces glucose uptake and malignant phenotypes in pancreatic ductal adenocarcinoma cells: an integrated bioinformatics and in vitro study.

Biochemical and biophysical research communications - 17 Sept 2026

Wei Yunyao, Huang Xiaolan, Mei Ying, Deng Kai

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) exhibits marked metabolic plasticity, but the effects of luteolin on glucose utilisation in PDAC cells remain unclear. We integrated predicted luteolin targets with bulk and single-cell transcriptomic data, weighted gene co-expression network analysis, machine-learning screening, protein-protein interaction analysis, independent-cohort evaluation, and survival analysis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42503269
DOI: 10.1016/j.bbrc.2026.154332

Genes

LGALS3
MET
SLC2A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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