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Rapid non-invasive prenatal screening test for trisomy 21 based on digital droplet PCR

22 Dec 2023

Abstract excerpt

Non-invasive prenatal tests for the detection of fetal aneuploidies are predominantly based on the analysis of cell-free DNA (cfDNA) from the plasma of pregnant women by next-generation sequencing. The development of alternative tests for routine genetic laboratories is therefore desirable. Multiplex digital droplet PCR was used to detect 16 amplicons from chromosome 21 and 16 amplicons from chromosome 18 as the...

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PMID: 38135736
DOI: 10.1038/s41598-023-50330-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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