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Microarray-Based Cell-Free DNA Analysis Improves Noninvasive Prenatal Testing

1 Jan 2014

Abstract excerpt

OBJECTIVE: To develop a microarray-based method for noninvasive prenatal testing (NIPT) and compare it with next-generation sequencing. METHODS: Maternal plasma from 878 pregnant women, including 187 trisomy cases (18 trisomy 13, 37 trisomy 18, 132 trisomy 21), was evaluated for trisomy risk. Targeted chromosomes were analyzed using Digital Analysis of Selected Regions (DANSR™) assays. DANSR products were...

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Share to Fetal and Pediatric Neurological Disorders
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PMID: 25228026
DOI: 10.1159/000367626

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