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Contribution of E190D and Q226H Mutations in HA to the Receptor-Binding Profile of D1.1 Genotype H5N1 Viruses.

Influenza and other respiratory viruses - 1 Jul 2026

Fang Yang, Yang Lei, Zou Shumei, Liu Liqi, Zhu Wenfei, Wang Dayan

Abstract excerpt

A 2024 human HPAI H5N1 case in British Columbia showed mixed viral populations containing HA-190D (28%) and HA-226H (35%) variants in tracheal aspirate sequencing. In this study, solid-phase binding assay and molecular docking were used to evaluate the contribution of HA-E190D/Q226H mutations to the viral receptor profiles. Our results showed that HA-E190D marginally reduced sialic acid α2,3 receptors' affinity,...

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Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A Virus, H5N1 Subtype

Share to Influenza, Human

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Identifiers

PMID: 42498495
DOI: 10.1111/irv.70298
PMCID: PMC13400179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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