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Article

Plasma Lipidomic Signatures Across the Healthy-Pre-COPD-COPD Continuum Identified by Machine Learning.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Xing Yeyiyi, Yu Guojing, Tian Qihui, Zhang Tongyi, Li Duoyang, Guo Yifan, Luo Xuqin, Li Wenyu, Liu Xiao, Xu Jiaqi, Li Jie

Abstract excerpt

Objective: Chronic obstructive pulmonary disease (COPD) imposes a substantial global burden, and Pre-COPD is regarded as an early, high-risk window that comprises distinct phenotypes, including small airway dysfunction (SAD), emphysema, and preserved ratio impaired spirometry (PRISm), whose early molecular heterogeneity is not fully captured by spirometry or imaging. This study aimed to characterize plasma...

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PMID: 42491704
DOI: 10.2147/COPD.S596991
PMCID: PMC13378510

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