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HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.

PloS one - 1 Jan 2026

Niu Miaomiao, Gao Jing, Han Xiaodong, Dong Ying, Wang Hui, Zhang Yue, Zhao Dongming, Wang Zijian, Qi Fang, Wang Feng, Meng Qiuye, Geng Jinjiao, Wu Shuqi, Wang Ying, Zhang Ying, Guo Chaoyang, Chen Hua

Abstract excerpt

Atherosclerosis is a chronic inflammatory disease with increasing prevalence in Northeast China, where HLA class II molecules play an important immunoregulatory role. However, the contribution of specific HLA-DRB1 and HLA-DQB1 alleles to AS susceptibility in this population remains incompletely characterized, necessitating novel biomarkers for early detection. In this case-control study of 209 participants,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42490569
DOI: 10.1371/journal.pone.0353906
PMCID: PMC13395462

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