Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated Seasonality of Childhood Type 1 Diabetes with Increasing Autoimmune Comorbidities: A 40-year Cohort Study.

Irish journal of medical science - 1 Aug 2026

Ozen Gulsum, Zanfardino Angela, Ozen Acan Gulsah, Acan Burak, Tinto Nadia, Iafusco Fernanda, Miraglia Del Giudice Emanuele, Aycan Zehra, Iafusco Dario

Abstract excerpt

BACKGROUND: Seasonal variation in the onset of Type 1 Diabetes Mellitus (T1DM) has long been recognized, yet little is known about how the severity of autoimmunity interacts with environmental triggers to influence disease manifestation. AIMS: This study aimed to elucidate the etiological interplay between seasonality, genetic predisposition, and immune dysregulation over a 40-year period. METHODS: A...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 1
Seasons
Male
Female
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

Age of Onset

Comorbidity

Child, Preschool

Autoimmune Diseases

Adolescent

Autoimmunity

Genetic Predisposition to Disease

Cohort Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42484831
DOI: 10.1007/s11845-026-04558-x
PMCID: PMC13588832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated Seasonality of Childhood Type 1 Diabetes with Increasing Autoimmune Comorbidities: A 40-year Cohort Study.PMID 42484831Read ↗

Seasonality in Type 1 Diabetes Mellitus and Other Autoimmune Diseases Based on Severity of Immunity: Elucidating the Etiology with 40 years of AnalysisSemantic proximity Read ↗

Seasonal Variation in the Time of Disease Manifestation in Finnish Children with Type 1 DiabetesSemantic proximity Read ↗

The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children.Semantic proximity Read ↗

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes.Semantic proximity Read ↗

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.Semantic proximity Read ↗

Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study.Semantic proximity Read ↗

Seasonality of month of birth of children and adolescents with type 1 diabetes mellitus in homogenous and heterogeneous populations.Semantic proximity Read ↗

Early childhood infections and the risk of islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).Semantic proximity Read ↗

Extending the Eisenbarth Model: Stage 0 as a Provisional Framework for Early Risk Stratification and Prevention in Type 1 Diabetes.Semantic proximity Read ↗

Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.Semantic proximity Read ↗

The Environmental Determinants of Diabetes in the Young (TEDDY) Study.Semantic proximity Read ↗

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.