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Article

Deep behavioral phenotyping reveals novel features in a mouse model of metabolic dysfunction-associated steatohepatitis.

Scientific reports - 21 Jul 2026

Sakamoto Naoaki, Numano Takamasa, Kobayashi Yui, Fukuda Masahiro, Osaki Maria, Omori Keisuke, Yamamoto Taichi, Murata Takahisa

Abstract excerpt

Patients with metabolic dysfunction-associated steatohepatitis (MASH) often suffer from a broad range of extrahepatic symptoms including fatigue and pruritus. However, evaluating behavioral abnormalities in preclinical mouse models remains challenging due to the limitations of conventional short-duration behavioral tests. This study aimed to comprehensively profile 24-hour behaviors of a MASH mouse model using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42481582
DOI: 10.1038/s41598-026-60820-3
PMCID: PMC13388975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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