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Article

The E205D mutation in CYP6P3 drives pyrethroid insecticide resistance in the African malaria mosquito vector Anopheles gambiae.

Science translational medicine - 4 Feb 2026

Kengne-Ouafo Jonas A, Kouamo Mersimine F M, Muhammad Abdullahi, Tepa Arnaud, Ntadoun Stevia, Mugenzi Leon M J, Tekoh Theofelix, Hearn Jack, Tchouakui Magellan, Wondji Murielle, Ibrahim Sulaiman S, Wondji Charles S

Abstract excerpt

Deciphering the molecular drivers of insecticide resistance is paramount to extending the effectiveness of malaria vector control tools. Here, we demonstrate that a P450 haplotype spanning a Glu205→Asp (E205D) amino acid point mutation in the CYP6P3 gene drives pyrethroid insecticide resistance in the mosquito malaria vector Anopheles gambiae. Pooled whole-genome DNA sequencing data from A. gambiae mosquitoes...

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PMID: 41637524
DOI: 10.1126/scitranslmed.ado6222

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