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Article

RNF144A as a potential risk gene for endometrial carcinoma: Insights from Mendelian randomization, bulk RNA sequencing, single-cell RNA, and experimental analysis.

Medicine - 4 Oct 2024

Ruan Xiqin, Wang Ni, Xie Qingwen, Du Yi

Abstract excerpt

Endometrial carcinoma (EC) is a prevalent gynecological malignancy that poses a significant threat to women's health worldwide. However, its pathogenesis and underlying mechanisms remains unclear. In this study, expression quantitative trait loci data, Mendelian randomization analysis, and differential expression analysis were performed to identify potential targets. A prognostic risk signature was subsequently...

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Identifiers

PMID: 39465767
DOI: 10.1097/MD.0000000000039886
PMCID: PMC11460862

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