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Article

Segmental duplications and supernumerary chromosomes drive antifungal drug resistance in Candida auris.

Nature communications - 10 Jul 2026

Narayanan Aswathy, Joshi Sameer, Harchand Ritika, Prasad Rajendra, Rudramurthy Shivaprakash M, Nishant Koodali T, Sanyal Kaustuv

Abstract excerpt

Candida auris, a World Health Organisation-listed critical priority fungal pathogen, causes frequent multidrug-resistant outbreaks worldwide. While point mutations underlying antifungal resistance are well characterised, the contribution of structural genomic variation to antifungal responses remains poorly defined. Here, we integrate whole-genome sequencing, a genome-wide copy number variation (CNV) screen,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42431934
DOI: 10.1038/s41467-026-75437-3
PMCID: PMC13483117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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