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Article

Checking Genetic Homogeneity Between Two Samples Using Summary Statistics With Application to Mendelian Randomization.

Statistics in medicine - 1 Jul 2026

Wang Kai, Wang Grace Z

Abstract excerpt

BACKGROUND: A common assumption in two-sample summary-data Mendelian randomization (MR) studies is that the effect of an instrumental single nucleotide polymorphism (SNP) on both the exposure and the outcome is consistent across the exposure and outcome samples. This assumption is more likely to hold when the minor allele frequency (MAF) of the instrumental SNP is similar in the two samples. However, in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42415357
DOI: 10.1002/sim.70663
PMCID: PMC13342494

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MAF

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