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Article

Functional analysis reveals G/U pairs critical for replication and trafficking of an infectious non-coding viroid RNA.

Nucleic acids research - 6 Apr 2020

Wu Jian, Zhou Cuiji, Li James, Li Chun, Tao Xiaorong, Leontis Neocles B, Zirbel Craig L, Bisaro David M, Ding Biao

Abstract excerpt

While G/U pairs are present in many RNAs, the lack of molecular studies to characterize the roles of multiple G/U pairs within a single RNA limits our understanding of their biological significance. From known RNA 3D structures, we observed that the probability a G/U will form a Watson-Crick (WC) base pair depends on sequence context. We analyzed 17 G/U pairs in the 359-nucleotide genome of Potato spindle tuber...

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Identifiers

PMID: 32083649
DOI: 10.1093/nar/gkaa100
PMCID: PMC7102988

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Source receipt: pubmed, retrieved 7 Sept 2026.

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