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Article

Microcystic Adnexal Carcinoma-like Neoplasm in a Patient With POT1 Mutation.

Cutis - 1 Apr 2026

Games Margaux P, Schwartz Laurel, Lipoff Jules B

Abstract excerpt

A 72-year-old man with a history of multiple cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), presented to the dermatology clinic for a regularly scheduled full-body skin examination and subsequently was diagnosed with microcystic adnexal carcinoma (MAC). He previously had been referred to a medical geneticist and was found to have a POT1 (protection of telomeres 1)...

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Aged
POT1 gene
Mutation
Shelterin Complex
Skin Neoplasms
Telomere-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42411896
DOI: 10.12788/cutis.1397

Genes

POT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Microcystic Adnexal Carcinoma-like Neoplasm in a Patient With POT1 Mutation.PMID 42411896Read ↗

A new POT1 germline mutation-expanding the spectrum of POT1-associated cancers.Semantic proximity Read ↗

Mutations in POT1 predispose to familial cutaneous malignant melanoma.Semantic proximity Read ↗

POT1 and multiple primary melanomas: the dermatological phenotype.Semantic proximity Read ↗

Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition SyndromeSemantic proximity Read ↗

Association of the POT1 Germline Missense Variant p.I78T With Familial MelanomaSemantic proximity Read ↗

Characterization of POT1 tumor predisposition syndrome: Tumor prevalence in a clinically diverse hereditary cancer cohort.Semantic proximity Read ↗

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.Semantic proximity Read ↗

Unusual suspects in hereditary melanoma: POT1, POLE, BAP1.Semantic proximity Read ↗

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POT1 loss-of-function variants predispose to familial melanoma.Semantic proximity Read ↗

POT1 tumour predisposition: a broader spectrum of associated malignancies and proposal for additional screening program.Semantic proximity Read ↗

POT1 tumor predisposition: a broader spectrum of associated malignancies and proposal for additional screening programSemantic proximity Read ↗

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