Variations in cross-neutralizing reactivity is dependent on mutations on immunogenic epitopes in the spike protein of SARS-CoV-2 variants.

doi:10.1016/j.ijmmb.2026.101207

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Article

Variations in cross-neutralizing reactivity is dependent on mutations on immunogenic epitopes in the spike protein of SARS-CoV-2 variants.

Indian journal of medical microbiology - 1 Jan 2026

Das Priti, Sapkal Gajanan N, Yadav Pragya D, Siddalingaiah Nayana, Varun Chakrakodi N, Ashwini M A, Kesavan Muralidharan, Desai Anita

Abstract excerpt

PURPOSE: The COVID-19 pandemic has witnessed the rapid evolution of the SARS-CoV-2 virus, resulting in the emergence of multiple variants with mutations in critical regions of the spike protein, notably in the receptor binding domain. These mutations can lead to immune evasion and breakthrough (BT) infections, even in the vaccinated individuals. While previous studies have documented various mutations, there is a...

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Topics

Humans
Spike Glycoprotein, Coronavirus
Antibodies, Neutralizing
SARS-CoV-2
Antibodies, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Epitopes

COVID-19

Cross Reactions

Neutralization Tests

COVID-19 Vaccines

Immune Evasion

Source

Open in PubMed

Identifiers

PMID: 42409113
DOI: 10.1016/j.ijmmb.2026.101207

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