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Article

Association between Modified Cardiometabolic Index and rheumatoid arthritis: the mediating role of phenotypic age acceleration.

Clinical rheumatology - 1 Sept 2026

Huang Wang, Xia Binwen, Yang Heng, Pan Hongtao, Liu Tingting, Hu Chunning

Abstract excerpt

BACKGROUND: Modified Cardiometabolic Index (MCMI) is a novel metabolic assessment metric integrating waist-to-height ratio (WHtR), lipid, and fasting plasma glucose (FPG). Rheumatoid arthritis (RA), as an autoimmune disease, is closely linked to metabolic status, yet the relation of MCMI to RA remains unclear. Phenotypic age acceleration (PAA), reflecting biological aging, possibly mediates the relation of MCMI...

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PMID: 42406254
DOI: 10.1007/s10067-026-08263-z

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