Article
Immunoglobulin G and plasma glycome in early rheumatoid arthritis differ from matched controls and link less fat-free mass to an accelerated aging phenotype: an exploratory study.
Arthritis research & therapy - 21 Apr 2026
Hashmi Sidra W, Andonian Brian J, Thompson Mary M, Bennett William C, Sudnick Alyssa M, Johnson Johanna L, Ross Leanna M, Collins-Bennett Katherine A, Belski Kelsey B, Vinicki Martina, Pribic Tea, Lauc Gordan, Krishnan Sridevi, Huffman Kim M
Abstract excerpt
BACKGROUND: In patients with rheumatoid arthritis (RA), the immunoglobulin G (IgG) glycome is altered and characterized by decreased galactosylation. The goals of our exploratory study were to identify (1) alterations in the IgG and plasma glycome and GlycanAge—a glycome-based biological age measure—in patients with early RA and (2) changes in the RA glycome following a lifestyle intervention. METHODS: IgG and...
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