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Challenges in ITS-based identification of Cunninghamella bertholletiae and Rhizopus microsporus due to intragenomic ITS sequence heterogeneity.

Microbiology spectrum - 4 Aug 2026

Wu Wan-Lin, Choi Pui-Ching, Wang Hsuan-Chen, Hsieh Ming-I, Wu Chi-Jung

Abstract excerpt

Cunninghamella bertholletiae and Rhizopus microsporus are clinically important Mucorales that frequently exhibit mixed peaks in chromatograms from conventional Sanger sequencing of the internal transcribed spacer (ITS) region. Intragenomic ITS heterogeneity has been reported in R. microsporus but has not yet been characterized in Cunninghamella species. This study investigated ITS patterns in nine C....

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PMID: 42405790
DOI: 10.1128/spectrum.03485-25
PMCID: PMC13436413

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