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Prioritizing stability-enhancing mutations using the ESM protein language model in conjunction with physics-based MM/GBSA predictions.

Protein engineering, design & selection : PEDS - 9 Jan 2026

Rhodes Emily R, Scarabelli Guido, Jou Jonathan, Byerly Jacob, Sprenger Kayla G, Oloo Eliud O

Abstract excerpt

Directed evolution for protein engineering, as currently practiced in the biotechnology and pharmaceutical industries, is both tedious and expensive. Computationally driven protein design has the potential to expedite the engineering process and generate high-quality variants at a lower cost than traditional approaches. We investigated the effectiveness of two different computational methods as triaging tools for...

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PMID: 42405694
DOI: 10.1093/protein/gzag016

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