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DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats.

Physiology & behavior - 15 Oct 2026

Miller Claire E, Met-Hoxha Erisa, Bonanno Gabrielle R, Krupke Linnaea, Kinzig Kimberly P

Abstract excerpt

Polycystic Ovary Syndrome (PCOS) is the most common reproductive-metabolic disorder in women of reproductive age, yet preclinical models show considerable variability in their ability to capture its multiple diagnostic phenotypes and various non-diagnostic features. Androgen-based rodent models are widely used to mimic clinical hyperandrogenism; however, studies using dehydroepiandrosterone (DHEA), the most...

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Dehydroepiandrosterone
Estrous Cycle
Fructose
Maze Learning
Ovary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Ovary Syndrome

Rats, Long-Evans

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PMID: 42398846
DOI: 10.1016/j.physbeh.2026.115435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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