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Article

Rodent models for human polycystic ovary syndrome.

Biology of reproduction - 1 May 2012

Walters Kirsty A, Allan Charles M, Handelsman David J

Abstract excerpt

Polycystic ovary syndrome (PCOS) is the most frequent female endocrine disorder, affecting 5%-10% of women, causing infertility due to dysfunctional follicular maturation and ovulation, distinctive multicystic ovaries and hyperandrogenism, together with metabolic abnormalities including obesity, hyperinsulinism, an increased risk of type 2 diabetes, and cardiovascular disease. The etiology of PCOS is unclear, and...

Topics

Androgens
Animals
Aromatase Inhibitors
Disease Models, Animal
Estrogens
Female
Humans
Leptin
Luteinizing Hormone
Mice
Mutation
Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasminogen Activator Inhibitor 1

Polycystic Ovary Syndrome

Progestins

Rats

Receptors, Leptin

Source

Identifiers

PMID: 22337333
DOI: 10.1095/biolreprod.111.097808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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