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Article

A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains.

mBio - 25 Apr 2023

Sala Arianna, Ardizzoni Andrea, Spaggiari Luca, Vaidya Nikhil, van der Schaaf Jane, Rizzato Cosmeri, Cermelli Claudio, Mogavero Selene, Krüger Thomas, Himmel Maximilian, Kniemeyer Olaf, Brakhage Axel A, King Benjamin L, Lupetti Antonella, Comar Manola, de Seta Francesco, Tavanti Arianna, Blasi Elisabetta, Wheeler Robert T, Pericolini Eva

Abstract excerpt

Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to pathogenic state, if only some strains can cause VVC, and/or if there is displacement of commensal strains with more pathogenic strains. We studied a set of VVC and...

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Identifiers

PMID: 36856418
DOI: 10.1128/mbio.00107-23
PMCID: PMC10128025

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