Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A self-reinforcing transcriptional loop: ELF5 directly activates the STAT5B promoter to orchestrate milk protein synthesis in water buffalo.

Journal of animal science - 8 Jan 2026

Gao Ruixia, Liu Yiduan, Huang Lige, Fan Xinyang, Zhang Yongyun, Miao Yongwang

Abstract excerpt

Signal transducer and activator of transcription 5B (STAT5B) plays a critical role in milk protein synthesis in mammals. However, its transcriptional regulatory mechanisms in buffalo, particularly in Binglangjiang buffalo, a breed characterized by high milk protein content, remain largely unclear. The study isolated and identified the functional STAT5B transcript variant in lactating buffalo mammary gland...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Buffaloes
Share to Caseins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Culture Techniques

Share to Cytoplasm

Share to Lactation

Share to Mammary Glands, Human

Share to Milk Proteins

Share to STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 42384185
DOI: 10.1093/jas/skag197
PMCID: PMC13384067

Genes

STAT5B
ELF5
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A self-reinforcing transcriptional loop: ELF5 directly activates the STAT5B promoter to orchestrate milk protein synthesis in water buffalo.PMID 42384185Read ↗

Identification of Hub Genes and Target miRNAs Crucial for Milk Production in Holstein Friesian Dairy Cattle.Semantic proximity Read ↗

Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development.Semantic proximity Read ↗

Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo.Semantic proximity Read ↗

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.Semantic proximity Read ↗

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.Semantic proximity Read ↗

Regulatory Network of MiRNAs, IncRNAs, Transcription Factors and Target Genes Associated With Immune Response in Bovine MastitisSemantic proximity Read ↗

Regulatory Network of miRNA, lncRNA, Transcription Factor and Target Immune Response Genes in Bovine MastitisSemantic proximity Read ↗

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancySemantic proximity Read ↗

Evolutionary analysis of buffalo sterol regulatory element-binding factor (SREBF) family genes and their affection on milk traits.Semantic proximity Read ↗

A comprehensive manually-curated Compendium of Bovine Transcription FactorsSemantic proximity Read ↗

Essential roles of stat5.1/stat5b in controlling fish somatic growth.Semantic proximity Read ↗

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.