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Article

Molecular Characteristics and Role of Buffalo SREBF2 in Triglyceride and Cholesterol Biosynthesis in Mammary Epithelial Cells.

Genes - 19 Feb 2025

Dao Wenbin, Chen Hongyan, Ouyang Yina, Huang Lige, Fan Xinyang, Miao Yongwang

Abstract excerpt

Background/Objectives: Sterol regulatory element-binding transcription factor 2 (SREBF2) is a key transcription factor involved in regulating cholesterol homeostasis. However, its role in buffalo mammary gland lipid metabolism remains unclear. Methods: To address this, we isolated and characterized the SREBF2 gene from buffalo mammary glands and performed an in-depth analysis of its molecular characteristics,...

Read the complete abstract on PubMed

Topics

Animals
Buffaloes
Cholesterol
Mammary Glands, Animal
Epithelial Cells
Sterol Regulatory Element Binding Protein 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Triglycerides

Polymorphism, Single Nucleotide

Lipid Metabolism

Lactation

Source

Open in PubMed Open full text

Identifiers

PMID: 40004566
DOI: 10.3390/genes16020237
PMCID: PMC11855135

Genes

ACACA
CD36
DGAT1
HMGCR
INSIG1
LPL
PPARG
SCD
SQLE

Variants

Provenance

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