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Article

Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression.

Life science alliance - 1 Sept 2026

Jiang Liqin, Wang Lijin, Zhou Lei, Wu Fangquan, Ma Johnny Kwok Kit, Yu Willie Ss, Koh James Hz, Chia Audrey Wl, Saw Seang-Mei, Ghosh Sujoy, Barathi Veluchamy A

Abstract excerpt

Myopia is a global cause of vision impairment, yet its molecular mechanisms remain unclear. We applied a multi-omics approach to the retina, choroid, and sclera of guinea pigs (GPs), a model of spontaneous myopia. Integrated transcriptomic and proteomic analyses suggest a two-state molecular framework. In a myopia-prone state, the choroid and sclera exhibited widespread transcript-protein discordance, with RNA...

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Choroid
Disease Susceptibility
Guinea Pigs
Multiomics
Myopia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42373541
DOI: 10.26508/lsa.202503595
PMCID: PMC13315480

Genes

CYP26A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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