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Article

From Genes to Imaging Phenotypes: Radiomics and Machine Learning as Tools to Decode Molecular Pathways in Alzheimer's Disease.

Genes - 8 Jun 2026

Rusek Marta, Pitucha Monika

Abstract excerpt

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder driven by complex interactions between genetic susceptibility, molecular pathways, and progressive brain alterations. Key genetic factors, including APOE, TREM2, and MAPT, contribute to pathological processes such as amyloid-β accumulation, tau aggregation, neuroinflammation, and synaptic dysfunction. Despite substantial advances in...

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Identifiers

PMID: 42353831
DOI: 10.3390/genes17060672
PMCID: PMC13299505

Genes

APOE
MAPT
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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