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Article

Intersection Between Systemic Autoimmune Diseases, Primary Immunodeficiency and Cancer: a Field in its Infancy.

Journal of clinical immunology - 25 Jun 2026

Sánchez-Ramón Silvia, Ramos-Lisbona Ana Isabel, Karim Mohammed Yousuf

Abstract excerpt

PURPOSE: Systemic autoimmune diseases and primary immunodeficiencies/inborn errors of immunity (PIDs/IEIs) have traditionally been viewed as opposing immunological entities. However, growing genetic, immunological, and clinical evidence challenges this dichotomy, revealing a shared spectrum of immune dysregulation, genetic vulnerability, and convergent phenotypes. Advances in next-generation sequencing have...

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Topics

Humans
Autoimmune Diseases
Neoplasms
Primary Immunodeficiency Diseases
Autoimmunity
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Susceptibility

Immunologic Deficiency Syndromes

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42350711
DOI: 10.1007/s10875-026-02030-0
PMCID: PMC13562287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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