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Article

Autoimmunity and primary immunodeficiency: two sides of the same coin?

Nature reviews. Rheumatology - 19 Dec 2017

Schmidt Reinhold E, Grimbacher Bodo, Witte Torsten

Abstract excerpt

Autoimmunity and immunodeficiency were previously considered to be mutually exclusive conditions; however, increased understanding of the complex immune regulatory and signalling mechanisms involved, coupled with the application of genetic analysis, is revealing the complex relationships between primary immunodeficiency syndromes and autoimmune diseases. Single-gene defects can cause rare diseases that...

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Identifiers

PMID: 29255211
DOI: 10.1038/nrrheum.2017.198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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