Article
Ascophyllan Supplementation Is Safe and Associated with Exploratory Modulation of Innate Immune Phenotypes, Biochemical Parameters, and the Gut Microbiome in a Randomized Pilot Trial.
Marine drugs - 15 Jun 2026
Mizuno Shohei, Espinoza Jorge Luis, Vu Lam Quang, Banno Hirona, Iida Yusuke, Shinohara Saki, Dac Do Tung, Nakagami Yuya, Uchino Kaori, Horio Tomohiro, Hanamura Ichiro, Asai Nobuhiro, Enomoto Megumi, Tani Hiroya, Nakayama Takayuki, Suzuki Susumu, Takami Akiyoshi
Abstract excerpt
BACKGROUND: Ascophyllan, a sulfated polysaccharide extracted from brown seaweed, has shown immunomodulatory and antioxidant effects in preclinical studies, yet human clinical evidence remains scarce. This randomized, double-blind, placebo-controlled pilot trial evaluated the safety and exploratory biological effects of daily ascophyllan supplementation in healthy adults. METHODS: Twelve participants were...
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