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Article

Whole exome sequencing and cluster analysis reveal that EPB41L4A mutation may trigger tooth agenesis.

PloS one - 1 Jan 2026

Li Tian-Qi, Zhang Qin, Wang Hui-Juan, Ma Zhao-Feng, Lu Bing-Yu, Hou Ke-Gui, Zhang Xiang-Yu

Abstract excerpt

OBJECTIVE: To detect and analyze the correlation between commonly mutated genes and known genes associated with tooth agenesis in patients with non-syndromic tooth agenesis. The aim is to explore new genes that may be associated with tooth agenesis, to provide a genetic reference for its prevention as well as for the clinical diagnosis and treatment of tooth agenesis. METHODS: Genomic DNA was extracted from the...

Read the complete abstract on PubMed

Topics

Humans
Anodontia
Cluster Analysis
Female
Mutation
Exome Sequencing
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Exome

Source

Open in PubMed Open full text

Identifiers

PMID: 42715212
DOI: 10.1371/journal.pone.0357667
PMCID: PMC13557372

Genes

EPB41L4A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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