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Genomic instability and biofilm determinants in Streptococcus mutans: insights from a sequence-defined arrayed transposon library.

Journal of bacteriology - 23 Jul 2026

Solano Morales Ana Karen, Cazano Emanuel, Pirani Cara, Jones Graysen, Goode Andrew, Walker Alejandro R, Sperduto Anthony, Dwivedi Bikash, Bantha Pallavi, Peter Stella D, McLellan Lisa K, Alam Mohamed A, Shields Robert C

Abstract excerpt

Streptococcus mutans is a primary architect of dental caries, utilizing complex genetic networks to build resilient, acid-producing biofilms. While pooled screens (Tn-seq) have identified important fitness factors, they often fail to capture extracellular or moderate-effect determinants due to community-level masking. Therefore, to study biofilm phenotypes, we constructed a comprehensive arrayed library of 9,216...

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Biofilms
Dental Caries
DNA Transposable Elements
Gene Library
Genome, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Instability

Streptococcus mutans

Whole Genome Sequencing

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Open in PubMed Open full text

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PMID: 42328873
DOI: 10.1128/jb.00174-26
PMCID: PMC13393454

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CP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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