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Emergence of an antigenically drifted and reassorted influenza B virus at the end of the 2024-25 influenza season.

mBio - 12 Aug 2026

Akin Elgin, Villafuerte David A, Werner Anne P, Pinsley Matthew, Pierce Corinne A, Fall Amary, Abdullah Omar, Norton Julie M, Rothman Richard E, Fenstermacher Katherine Z J, Gong Yu-Nong, Klein Eili, Mostafa Heba H, Pekosz Andrew

Abstract excerpt

Influenza B virus (IBV) is a significant contributor to annual and severe cases of influenza, particularly in the young and elderly. Late in the 2024-25 Northern Hemisphere influenza season, a surge of IBV cases was identified in the Johns Hopkins Hospital Systems. The IBV responsible for the surge, C.3.1/re, was a clade C.3 virus that had reassorted with clade C.5.1 viruses and acquired the D197N mutation in...

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Identifiers

PMID: 42328860
DOI: 10.1128/mbio.01198-26
PMCID: PMC13463853

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