Article
Molecular diversity and evolutionary dynamics of phage receptor binding proteins in Staphylococcus aureus: implications for phage therapy and resistance.
Scientific reports - 18 Jun 2026
VinodKumar C S, Prasad B S, Arunkumar A, Najar Ishfaq Nabi, Singh Aarti, Emilda J K Veni, Venkatesh R, Sivaji Vikram, Jayasimha V L, Arakera Suresh Basavaraj, Kalasuramath Suneeta, Ramesh N, Veeraraghavan Balaji
Abstract excerpt
Phage-host interactions are defined by the molecular specificity of receptor-binding proteins (RBPs), which determine the efficacy of infection and the host range. The genetic and structural variability of bacterial receptor molecules is essential for designing effective phage therapeutics and mitigating resistance. This study investigated four receptor-binding proteins, tarS, tarL, tagO, and tagG, in multiple...
Read the complete abstract on PubMedTopics
- Staphylococcus aureus
- Molecular Docking Simulation
- Evolution, Molecular
- Polymorphism, Single Nucleotide