Article
Analysis of phage resistance in Staphylococcus aureus SA003 reveals different binding mechanisms for the closely related Twort-like phages ɸSA012 and ɸSA039.
Applied microbiology and biotechnology - 1 Oct 2018
Azam Aa Haeruman, Hoshiga Fumiya, Takeuchi Ippei, Miyanaga Kazuhiko, Tanji Yasunori
Abstract excerpt
We have previously generated strains of Staphylococcus aureus SA003 resistant to its specific phage ɸSA012 through a long-term coevolution experiment. However, the DNA mutations responsible for the phenotypic change of phage resistance are unknown. Whole-genome analysis revealed eight genes that acquired mutations: six point mutations (five missense mutations and one nonsense mutation) and two deletions....
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