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Article

Whole-genome sequencing reveals hidden antimicrobial resistance genes in phenotypically susceptible probiotic candidate lactic acid bacteria.

Scientific reports - 18 Jun 2026

Disastra Yuda, Wongsurawat Thidathip, Jenjaroenpun Piroon, Hampson David John, Kamwa Ratchnida, Prapasarakul Nuvee

Abstract excerpt

Phenotypic assays commonly used to evaluate probiotic safety may fail to detect clinically relevant antimicrobial resistance (AMR), potentially allowing genetically concerning strains to appear acceptable based on MIC testing alone. To explore this issue, we applied whole-genome sequencing (WGS) to three lactic acid bacteria (LAB) isolates previously identified as probiotic candidates based on acid and bile...

Read the complete abstract on PubMed

Topics

Probiotics
Whole Genome Sequencing
Drug Resistance, Bacterial
Animals
Genome, Bacterial
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Anti-Bacterial Agents

Lactiplantibacillus plantarum

Swine

Chickens

Lactobacillales

Source

Open in PubMed Open full text

Identifiers

PMID: 42315553
DOI: 10.1038/s41598-026-57518-x
PMCID: PMC13550537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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