Article
The impact of FBN1 variant types on pregnancy-related aortic dissection in women with Marfan syndrome.
International journal of cardiology - 1 Oct 2026
Yokouchi-Konishi Tae, Aoki-Kamiya Chizuko, Tsuritani Mitsuhiro, Ishihara Yasuki, Miyashita Yohei, Asano Yoshihiro, Yagyu Takeshi, Matsuda Hitoshi, Morisaki Hiroko, Temukai Mai, Sawada Masami, Kakigano Aiko, Iwanaga Naoko, Kanagawa Takeshi, Neki Reiko, Yoshimatsu Jun
Abstract excerpt
BACKGROUND: Pregnancy in women with Marfan syndrome (MFS) increases the risk of aortic dissection, yet management based solely on aortic root diameter often fails to predict this complication, particularly Stanford type B dissection. Haploinsufficient (HI) FBN1 variants are associated with more severe aortic phenotypes. We investigated the relationship between FBN1 genotype and pregnancy-related aortic dissection...
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