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Article

[Morphological and molecular-genetic evolution of the endometrial polyp to adenocarcinoma].

Arkhiv patologii - 1 Jan 2026

Chernev A A, Kravtcova E D, Popova A K, Abasov R Kh, Filipenko M L, Druy A E, Raskin G A

Abstract excerpt

Atypical endometrial hyperplasia and endometrial adenocarcinoma are successive stages of malignant transformation of the uterine epithelium. Usually genomic instability and tumor mutation burden progressively increase during carcinogenesis. In case of endometrial cancer, the presence of a mutation in the exonuclease domain of the POLE gene and/or a DNA mismatch repair deficiency (dMMR) leads to genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42313847
DOI: 10.17116/patol20268803173

Genes

POLE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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