Article
[Endometrial carcinoma: molecular classification in routine pathology].
Pathologie (Heidelberg, Germany) - 1 Sept 2024
Siebolts Udo, Schömig-Markiefka Birgid, Siemanowski-Hrach Janna, Merkelbach-Bruse Sabine
Abstract excerpt
The molecular classification of endometrial carcinoma defines four main groups: polymerase‑ɛ(PolE) gene mutated, microsatellite unstable (MSI), p53 abnormal tumors and tumors with no specific molecular profile (NSMP). This classification provides significant insights into the prognosis and therapeutic decisions. Each group exhibits unique genetic profiles identified through immunohistochemistry and molecular...
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