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Article

Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation Profile.

The American journal of surgical pathology - 1 Sept 2026

Park Kyung, Wang Yuxiu, Kim Kisong, Serrano Jonathan, Chen Fei, Vasudevaraja Varshini, Feng Xiaojun, Mirsadraei Leili, Snuderl Matija, Deng Fang-Ming

Abstract excerpt

Papillary renal neoplasm with reverse polarity (PRNRP) has been proposed as a distinct subtype of renal cell neoplasm with recurrent KRAS mutations and indolent behavior. However, its epigenetic landscape is poorly understood. In this study, 12 PRNRPs and a PRNRP initially diagnosed as "papillary adenoma" were analyzed. All 13 cases underwent targeted next-generation sequencing for driver mutations. Eleven PRNRPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42302390
DOI: 10.1097/PAS.0000000000002568

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation Profile.PMID 42302390Read ↗

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