The global burden and trends of thyroid cancer attributable to high BMI, and the causal impact of obesity: A study integrating GBD 1990-2021 and bidirectional Mendelian randomization.

Abstract excerpt

We assessed the global burden of thyroid cancer caused by high body mass index (BMI) from 1990 to 2021 and evaluated whether obesity is genetically supported as a causal risk factor using bidirectional Mendelian randomization (MR). First, we utilized the Global Burden of Disease (GBD) to estimate the deaths, disability-adjusted life years (DALYs), years lived with disability, and years of life lost (YLLs)...

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