Sex and context differences in the effects of trauma on comorbid alcohol use and post-traumatic stress phenotypes in actively drinking rats.

doi:10.1002/jnr.24972

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Article

Sex and context differences in the effects of trauma on comorbid alcohol use and post-traumatic stress phenotypes in actively drinking rats.

Journal of neuroscience research - 1 Dec 2021

Kirson Dean, Steinman Michael Q, Wolfe Sarah A, Spierling Bagsic Samantha R, Bajo Michal, Sureshchandra Suhas, Oleata Christopher S, Messaoudi Ilhem, Zorrilla Eric P, Roberto Marisa

Abstract excerpt

Alcohol use disorder (AUD) and affective disorders are frequently comorbid and share underlying mechanisms that could be targets for comprehensive treatment. Post-traumatic stress disorder (PTSD) has high comorbidity with AUD, but comprehensive models of this overlap are nascent. We recently characterized a model of comorbid AUD and PTSD-like symptoms, wherein stressed rats receive an inhibitory avoidance...

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PMID: 34687080
DOI: 10.1002/jnr.24972
PMCID: PMC8712392

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