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Article

Intestinal SMARCA4-deficient undifferentiated carcinoma: a case series and systematic review of the literature.

World journal of surgical oncology - 13 Jun 2026

Ma Wenjing, Zhou Shenda, Huang Yongta, Tang Xiaofeng, Wang Shimei

Abstract excerpt

BACKGROUND: Intestinal SMARCA4-deficient undifferentiated carcinoma (SMARCA4-DUC) is a rare and highly aggressive malignancy. Its clinicopathological features remain poorly defined. No standardized treatment has been established. METHODS: We report two new cases and review 18 previously published cases, providing a descriptive summary of clinicopathological, molecular, and therapeutic features. RESULTS: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42286625
DOI: 10.1186/s12957-026-04450-z
PMCID: PMC13491671

Genes

SMARCA4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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