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Article

Adaptive laboratory evolution of Methylorubrum extorquens for lanthanide-dependent robust growth under high concentrations of methanol.

Journal of bioscience and bioengineering - 1 Sept 2026

Chiba Tsuneyoshi, Fukui Toshiaki, Orita Izumi

Abstract excerpt

Methylorubrum extorquens AM1 has been extensively studied as a platform for biomanufacturing using a methanol feedstock. Given that lanthanide (Ln) ions are recognized as important metals related to methylotrophy of methylotrophic bacteria, this study applied adaptive laboratory evolution to M. extorquens under Ln-supplemented conditions to obtain strains with robust growth at high concentrations of methanol. The...

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PMID: 42285815
DOI: 10.1016/j.jbiosc.2026.05.007

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