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Article

Sensitive life-stage periods and genetic susceptibility in the association between air pollution and ischaemic stroke risk: a Bayesian life-course analysis.

Journal of epidemiology and community health - 10 Sept 2026

Wei Shengtao, Chen Lan, Chen Ge, Tian Fei, Zheng Dashan, Hu Peng, Ran Shanshan, Xiao Jianru, Yang Zijun, Wang Qinzhou, Lin Hualiang

Abstract excerpt

BACKGROUND: Air pollution exposure has been linked to ischaemic stroke (IS), yet the sensitive life stages for pollution-related IS risk and the interplay of genetic susceptibility remain unclear. METHODS: We analysed 404 234 IS-free participants from a large UK prospective cohort. Exposures to PM2.5, SO2 and O3 were estimated across five life stages (toddlerhood, childhood, adolescence, youth and middle-aged to...

Read the complete abstract on PubMed

Topics

Humans
Bayes Theorem
Air Pollution
Genetic Predisposition to Disease
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Environmental Exposure

United Kingdom

Middle Aged

Prospective Studies

Male

Ischemic Stroke

Air Pollutants

Particulate Matter

Gene-Environment Interaction

Adult

Genetic Risk Score

Adolescent

Child

Source

Identifiers

PMID: 42276766
DOI: 10.1136/jech-2026-226064

Provenance

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