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Article

Clinical implications of serum total VEGF-A and VEGF-A isoforms in patients with EGFR-mutated advanced non-small cell lung cancer treated with EGFR-TKIs.

International journal of clinical oncology - 1 Aug 2026

Hirakawa Tetsu, Yamaguchi Kakuhiro, Shimoji Kiyofumi, Sakamoto Shinjiro, Horimasu Yasushi, Masuda Takeshi, Nakashima Taku, Iwamoto Hiroshi, Hamada Hironobu, Hattori Noboru

Abstract excerpt

BACKGROUND: Vascular endothelial growth factor (VEGF)-A, which is overexpressed in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), has been implicated in resistance to EGFR-tyrosine kinase inhibitors (TKIs). VEGF-A comprises several isoforms, including VEGF121 and VEGF165. However, the clinical potential as blood biomarkers in EGFR-TKI treatment remains unclear. METHODS: We...

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Identifiers

PMID: 42262689
DOI: 10.1007/s10147-026-03083-2
PMCID: PMC13401580

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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