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PM2.5 promotes lung cancer progression by upregulating CTSL to relieve autophagic flux blockade and enhance the malignant cellular phenotype.

Ecotoxicology and environmental safety - 1 Sept 2026

Zhang Can, Xu Feiyi, Wu Sihan, Li Miao, Li Yang, Guo Mengzhe, Liu Yong, Zhang Youwei

Abstract excerpt

Ambient fine particulate matter (PM2.5) has been widely confirmed to severely threaten human health and is closely associated with the development and progression of respiratory diseases such as chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. This study aimed to investigate the key molecular targets and mechanisms by which PM2.5 induces lung cancer progression. Using an in vitro model,...

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Identifiers

PMID: 42248036
DOI: 10.1016/j.ecoenv.2026.120346

Genes

CTSL
SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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