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Protective efficacy of mutant strains of Borrelia burgdorferi as potential reservoir host-targeted biologics against Lyme disease.

Infection and immunity - 14 Jul 2026

Kumaresan Venkatesh, Smith Trever C, Lumbreras Miranda, MacMackin Ingle Taylor, Kilgore Nathan, Starling-Lin Jolie F, Horn Elizabeth J, Seshu J

Abstract excerpt

Lyme disease (LD), caused by Borrelia burgdorferi (Bb), is the most common vector-borne disease in the United States. Novel strategies to control transmission of Bb to humans via ticks are critical for the prevention of LD. One such strategy is to leverage non-infectious mutant strains of Bb for pathogen-derived biologics to block Bb transmission during the natural infectious cycle. Deletion of Borrelia...

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Antibodies, Bacterial
Bacterial Vaccines
Borrelia burgdorferi
Disease Reservoirs
Ixodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C3H

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Identifiers

PMID: 42234535
DOI: 10.1128/iai.00210-26
PMCID: PMC13367066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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