Article

Complicated Common Variable Immunodeficiency is Driven by Aberrant IL-10/IL-21 Signaling and Predisposed Polygenic Risk

2022-06-21

Abstract excerpt

<h4>Background</h4> The inborn errors of immunity (IEI) that include defective antibody responses are clinically heterogenous, especially the common variable immunodeficiency (CVID) phenotype that includes low immunoglobulin levels and impaired humoral responses to antigens. Beyond recurrent infections, many with the CVID phenotype develop non-infectious complications (NICs), including autoimmunity and lymphoproli...

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Literature Corpus work: 92a4ce6e-cb47-5093-9555-ee4a84d229fe
DOI: 10.1101/2022.06.20.22276681

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