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Article

Choosing wisely-directed HFE testing improves diagnostic yield and test utilization in hereditary hemochromatosis.

Clinical biochemistry - 1 Aug 2026

Nfonsam Landry E, Hohenadel Betty-Ann, Pai Menaka, Waye John S

Abstract excerpt

BACKGROUND: Appropriate laboratory test utilization is essential for sustainable clinical and laboratory practice. HFE-associated hereditary hemochromatosis is a common cause of iron overload in individuals of Northern European ancestry and is primarily associated with the p.(Cys282Tyr, C282Y) variant and, less frequently, p.(His63Asp, H63D). In 2019, Choosing Wisely Canada (CWC) recommended restricting HFE...

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Identifiers

PMID: 42217717
DOI: 10.1016/j.clinbiochem.2026.111146

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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