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Article

Clonal origin and early lineage divergence in adenosquamous carcinoma.

Cell reports - 23 Jun 2026

Poulain Florian, Malassigné Victor, Roncarati Patrick, Puech Julien, Imbeaud Sandrine, Zucman-Rossi Jessica, Crum Christopher P, Delvenne Philippe, Hubert Pascale, Péré Hélène, Veyer David, Herfs Michael

Abstract excerpt

Cancers of distinct histological subtypes are traditionally thought to arise from different cells of origin. However, alternative models propose that multipotent epithelial progenitors or late-stage transdifferentiation events may give rise to diverse tumor lineages, leaving the pathogenesis of adenosquamous carcinomas unresolved. Given the universal involvement of high-risk human papillomavirus in cervical...

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PMID: 42207638
DOI: 10.1016/j.celrep.2026.117470

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